Objective:To investigate the transmession characteristics of explosive blast in biological tissue.Materials:The transmission characteristics of explosive blast in liver,lung,vessel and tissue under skin were studied through blast pressure detection,and compared with in air.Results:The results showed that,the decline speed of the explosive blast in different media is in order:air>skin>blood;the sensitivity of different tissue on the explosive blast is in order:brain>chest>liver.The transmission to brain mainly is by vibrating through bone,which is dif-ferent from other parts of the body.Conclusion:The results can provide the basis for simulation study in vitro,and can also provide the theoretic basis for diagnosis and treatment of the explosive blast injury.