Abstract: Biomechanical properties of bone provide important and direct reference for osteoporosis prediction and assessment. However, it remains difficult to achieve non-invasive assessment of biomechanical properties of osteoporosis patient in clinic. Thus, developing indirect method to predict the biomechanics of bone is profound and valuable both in osteoporosis research and in clinic application. In this paper, current studies on prediction of biomechanical properties of osteoporosis bone are reviewed, and its future advances are also in prospect.