Objective To provide a quantitative analysis tool by building a mathematical model of seasickness habituation to make adaptive training plans scientifically for anti-seasickness purpose. Methods Based on the regular pattern of seasickness habituation, an exponential model of motion sickness incidence (MSI) was established to extract such seasickness habituation parameters as anti-motion sickness incidence (AMSI) and anti-motion sickness rate (μ) through making the seasickness habituation data fitting into the corresponding training, and the effects of AMSI and μ on MSI was also simulated. Results The data from two marine adaptive trainings were well fitted with the MSI model, and the fitting results of AMSI and μ were 0.87 and 0.048 for intermittent training, or 0.81 and 0.34 for continuous training. Effects of seasickness habituation training would be enhanced by increasing the value of AMSI and μ. Conclusions The present model of MSI is suitable for evaluating the effect of training on anti-seasickness and making the optimal strategy for such seasickness habituation training.