Cell migration is a basic physiological activity of cells. Cell migration not only plays an important role in vascular reconstruction, inflammatory response, tissue development, wound healing, etc. , it is also related to the invasion and metastasis of cancer cells. Plectin (499-533 kDa) is a macromolecular skeleton protein widely expressed in various tissues and cells. It has important biological functions and participates in many physiological and pathological processes of cells. Plectin can affect migration by regulating the cytoskeleton and through related signaling pathways. This review focused on the role of plectin in cancer cell migration and its related molecular mechanisms, and provided the theoretical basis to further understand and study the relationship between plectin and cancer cell migration and its targeted intervention.