球扩式介入主动脉瓣膜支架抗迁移力学行为研究
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江苏大学机械工程学院

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Study on anti-migration mechanical behavior of balloon-expanded interventional aortic valve stent
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    摘要:

    摘要:目的:介入心脏瓣膜支架置换术后瓣膜支架的锚定性(即抗迁移力学行为)是影响手术成功和远期疗效的关键因素,因此,本文研究球扩式主动脉瓣膜支架植入后的抗迁移力学行为。方法:建立球扩式瓣膜支架介入主动脉瓣膜后的抗迁移力学模型,采用数值模拟方法研究不同瓣环椭圆率、摩擦系数、瓣膜支架材料及自体瓣叶钙化情况对瓣膜支架抗迁移力的影响规律。结果:主动脉瓣环椭圆率为0.2、0.3、0.4、0.5时对应的最大抗迁移力分别为12.37N、10.94N、8.5N、4.75N;当摩擦系数为0.1、0.2、0.3时,瓣膜支架的最大抗迁移力分别为13.1N、11N、8.98N;L605钴铬合金制成的瓣膜支架的锚定性要优于316L不锈钢制成瓣膜支架的锚定性,其对应的最大抗迁移力分别为13.1N和9.82N;当自体瓣叶发生钙化时,最大抗迁移力为13.1N,而未钙化时最大抗迁移力仅为5.51N,相比而言降低了57.9%。结论:随着主动脉瓣瓣环椭圆率的不断增大,瓣膜支架的锚定性逐渐降低;随着瓣膜支架与组织间的摩擦系数不断增大,最大抗迁移力也不断增大;L605钴铬合金制成的瓣膜支架要比316L不锈钢制成瓣膜支架的锚定性能优异;瓣膜发生钙化情况下瓣膜支架的锚定性要优于未发生钙化时的锚定性;本文的研究结论将为抗迁移瓣膜支架的结构设计和临床选择提供重要的科学依据。

    Abstract:

    ABASTRACT: Objective:Anchorage of valve stent (i.e. anti-migration mechanical behavior) after interventional cardiac valve stent replacement is the key factor that affects the success and long-term effect of the operation. Therefore, this paper studies the anti-migration mechanical behavior of balloon-expanded aortic valve stent after implantation. Methods: A mechanical model of anti-migration of balloon-expanded valve stent after interventional treatment of aortic valve was established. The effects of different valve ring ellipticity, friction coefficient, valve stent material and calcification of autogenous valve leaflet on anti-migration of valve stent were studied by numerical simulation. Results: When the ovality of aortic valve ring is 0.2, 0.3, 0.4 and 0.5, the corresponding maximum migration force was 12.37N, 10.94N, 8.5N and 4.75N respectively; When the friction coefficient is 0.1, 0.2 and 0.3, the migration force of valve stent is 13.1N, 11N and 8.98N respectively; The anchoring performance of valve stent made of L605 cobalt-chromium alloy is better than that made of 316L stainless steel, and its corresponding maximum anti-migration force is 13.1N and 9.82N respectively; When the autogenous valve is calcified, the maximum migration force is 13.1N, while when the autogenous valve is not calcified, the maximum migration force is only 5.51N, The latter is 57.9% lower than the former. Conclusion: With the increase of the ovality of the valve ring, the anchoring of the valve stent decreases gradually; As the friction coefficient between the valve stent and the tissue increases, the migration force also increases; The anchoring performance of valve stent made of L605 cobalt-chromium alloy is superior to that made of 316L stainless steel; The anchoring of valve stent under calcification is better than that without calcification;The conclusions of this study will provide important scientific basis for the structural design and clinical selection of anti-migration valve stent.

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  • 收稿日期:2023-03-02
  • 最后修改日期:2023-04-04
  • 录用日期:2023-04-11
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