Objective The influence of stent and balloon shape on hemodynamics was studied in tapered vessels with multiple stenosis. Methods The hemodynamic model was established after the implantation of vascular stent in tapered vessel with multiple stenosis. The numerical simulation method was used to study the effect of the combination of different shaped stents and balloons on postoperative hemodynamics. Results When the cylindrical stent was expanded using cylindrical balloon and tapered balloon respectively, the use of tapered balloon for expansion can produce less low-speed blood flow and low TAWSS areas; When tapered balloon was used to expand cylindrical stent and tapered stent respectively, expanding the cylindrical stent can generate less low-speed blood flow and low TAWSS areas. Conclusions The hemodynamic environment of tapered vessel with multiple stenosis was influenced by the shape of stent and balloon. The use of tapered balloon to expand cylindrical stent in tapered vessels with multiple stenosis can achieve favorable hemodynamic environment and reduce the possibility of ISR.The research conclusion of this paper can provide scientific basis for the rational formulation of clinical intervention scheme.