Objective: To analyze the interface biomechanical properties between femora and prosthesis. Methods Theory models of bending and torsion for non-homogeneous layer-like materials were used to quantify the stress distribution when the femora were loaded in single foot stance and stance from seating, both before and after the replacement of different prosthesis. Results As the material properties of interface were different between bone and prosthesis, the bigger the difference, the greater the stress was in the result in the interface of losing, stripping and damage. Difference in young's modulus of the different prosthesis resulted in different levels of stress shielding. Conclusion The prosthesis with composite materials significantly reduced stress shielding. The hydroxyapatite-coated prosthesis helped to reduce stress difference at bone and prosthesis interface.