Advances in computer-aided technology and its integration with biology, engineering, and information technology to tissue engineering application have developed a new field of computer-aided tissue engineering(CATE).This emerging field encompasses computer-aided design,imaging process, manufacturing, and solid freeform fabrication for modeling, designing, simulation, and manufacturing of biological tissue and organ substitutes. This paper presents some salient advances in this field, particularly in computer-aided tissue modeling, computer-aided tissue informatics, and computer-aided tissue scaffold design and fabrication. Methodologies of development of CATE modeling from high resolution non-invasive imaging and image-based 3D reconstruction, and various reconstructive techniques for CAD based tissue modeling generation will be described. The latest development in solid freeform fabrication to tissue engineering and a framework of bio-blueprint modeling for 3D cell and organ printing will also be introduced.