Objective Bone tissue has a optimal structure, which could present a typical example to show how the structure-function of bone controlled by biomechanics The mechanics plays an important role in the growing, reconstructing and shaping of bone. But up to now it has not been able to essentially illustrate this mechanic stimulation The bone tissue is a kind of porous struction and its deformation resulted from mechanic loading can cause fluid flow to make the effect on bone cells, which also has been proved by the vitro experiments. So the flow shear stress is one of the important factors when study bone tissue controlled by mechanic loaded, The present study on the flow shear stress mainly shows the effective function of theflows, the bio-reaction of cells and the mechanic transmission researched by the flow shear stress in cells.Many of these studies indicated that at least in part fluid shear stress is concerned with the mechanotransduction in bone tissue