Objective With cryosectional images sequence as data source, bone structure curve and surface modelsare reconstructed. Methods Registration is firstly applied to all the cryo-sectional images through translation, rotationand scaling transforms. Segmentation is then performed on every single image. Characteristic boundary points areselected and fitted into cubic Nurbs curves. B-spline local modification property is utilized to adjust the control polygon forthe fitted curve to better approximate the bone structure boundary. All the segmented curves are added to the curvedatabase with bone name, orientation and cryo-sectional image number combined into an index. Results A comprehensivetechnical solution to bone structure curve and surface modeling from cryo-sectional images is presented, and surfacemodels database is established. Conhclusion The technical solution to reconstruct curve and surface models fromcryo-sectional images is feasible and effective.