Objective We produced a model by given alcohol orally in order to study the effects of little ethanol on bone biomechanics property of growing mice. Methods Thirty six-week-old KM mice, clean grade, half male and half female, initially weighing 25~35g, were randomly divided into 3 groups. These groups were basal control which were killed at the beginning of the experiment; intact control that were given distilled water with 10 ml?kg^(-1)?d^(-1), 50%(V/V) ethanol group (Model) according to the dosage of 4g?kg^(-1)?d^(-1) for 60 days. All mice were killed by taken out their eyeball to collect the forth lumbar vertebra and right femur for testing biomechanical properties including Indentation Test of vertebra and fall-loading test of proximal femoral neck. Result Maximal resistibility of lumbar vertebra decreased 63.6% significantly (P<0.01) and structural mechanical strenth of right proximal femoral neck declined (-29.4%, P<0.01) in Model group, Conclusion Little ethanol had badly affected biomechanical properties including vertebra and proximal femoral neck in growing mice.