Objective To establish a three-dimensional (3D) geometrical and gridding model of human heart, and carry out the finite element (FE) simulation. Method With visible data of digital human heart, a 3D structures of the heart s configurations and interior structures are constructed by software 3D-DOCTOR and SOLIDWORKS. The model has been imported into FE software ABAQUS by format STEP. The natural frequency and the stresses of the model are analyzed under the blood pressure. Result The digital model of the human heart has been developed, which could provide the 3D configurations and interior structures as well as the volume of the heart. The different mechanics behaviors in different regions within the heart has been demonstrated. The frequency and the stresses of the heart from 3 different regions have been obtained under blood pressure. Conclusions A 3D visualization geometrical and gridding model of the heart is developed by digital human data, which can show the configurations and internal structures of the heart. By using FE method, the model can be used to provide a visualization numerical simulation platform for biomechanics analysis of the heart.