Bone can adapt to external mechanical loading,forming or resorbing bone tissue at the specific site in order to increase the efficiency of its mechanical function.Additionally,bone has ability to repair micro-cracks timely,which occur as a result of daily loading activities,to prevent fracture and prolong bone's life.This is termed the Bone Functional Adaptation.Compared to traditional experiments,computational simulations embody many advantages in controllable,feasibility and predictability,being paid extensive attention.Because of the significance of theoretics of mechanobiology and practice of clinical medicine,the purpose of this article is to review the progress that has been made in simulating the mechanisms of bone functional adaptation.