Objective Aims of this study were to investigate the mechanical properties of Ultra-high molecular weight polyethylene carrying Alendronate (UHMWPE-ALN) and to explore its potential application in clinic. Materials and Methods The UHMWPE-ALN samples and the control UHMWPE were prepared by hot-pressure. The tensile test, small punch test, micro hardness, the Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD) were applied to measure the mechanical properties, the crystallinity and the phase of UHMWPE, respectively. Results ALN showed no effect on Young’s modulus, Yield strength and Hardness of UHMWPE. But Ultimate elongation, Ultimate strength and Work to failure of UHMWPE decreased significantly with adding ALN. DSC and XRD analyses showed that the crystallinity of UHMWPE-ALN decreased slight whereas no phase changes occurred in UHMWPE with added ALN. Conclusion It is feasible to fabricate UHMWPE-ALN with satisfied mechanical properties compared to the control UHMWPE when the content of ALN is lower than 0.25 wt%. The decreased crystallinity of UHMWPE-ALN is the major factor responsible for the decrease in mechanical properties.