The intracellular calcium signaling, which is modulated by the microenvironment of cells, is closely related to the cell's self renewal, differentiation, proliferation, and its apoptosis. The study on the quantitative modulation of the intracellular calcium signals could not only help to understand the dynamic behavior of such kind of signaling, but also play a significant role in the control of cell fate, simulation of cell behavior and bionics of cellular biological systems. This paper briefly reviewed the progress on the quantitative modulation of intracellular calcium signals induced by shear flow, including (1) experimental phenomena and the associated mechanisms of shear flow activated intracellular calcium response; (2) mathematical modeling and simulation of the intracellular calcium response induced by shear flow; (3) feedback control of the intracellular calcium signals by shear flow.