Objective To investigate the effects of different stent parameters on the development of restenosis, so as to provide references and basis for the design of stent forms. Methods Stents were categorized into groups according to stent unite length, strut number, strut cross-section diameter, stent depth into fluid, strut cross-section shape. The influence of different parameter settings on wall shear stress distributions was investigated based on three-dimensional computational fluid dynamics (CFD) simulation. Results The strut cross-section diameter had the most obvious impact on wall shear stress. It would lead to the increase of low wall shear stress area with shorter stent unite length, more strut number, larger strut cross-section diameter and deeper stent depth into the fluid. In comparison with triangular and square cross-section shape, the low shear stress area was much smaller by using stent with circular cross-section. Conclusions It is suggested that the circular cross-section shape should be adopted in stent design, with preference to reducing strut cross-section diameter, strut number and stent depth into the fluid, while increasing stent unite length.