Objective To analyze the hemodynamic parameters of Stanford type B aortic dissection based on computational fluid dynamics (CFD), so as to make a thorough evaluation of the disease. Methods Based on CTA images of a patient with complex Stanford type B aortic dissection, the three-dimensional model and hemodynamic numerical simulation were carried out to analyze the velocity distribution of flow field and intersecting fracture profile, as well as the wall shear stress. Results The maximum velocity of blood flow at the entry tear and re-entry tear could reach 1.2 m/s and 2 m/s, respectively, providing references for further evaluation on aortic rupture position and prediction of aortic rupture risk. An obvious low wall shear stress zone was formed on false lumen wall near the entry tear, which was consistent with the thrombus position in the patient. Conclusions CFD could effectively analyze the hemodynamic characteristics of complex aortic dissection, obtain the correlation between aortic dissection and wall shear stress at aorta arch and descending aorta, which contributed to guiding clinical assessment of aortic function for preventing the diseases.