Bone remodeling can keep the biomechanical properties, which is of great significance to maintain bone strength. Normal skeletal development requires tight coordination of transcriptional networks, signaling pathways and biomechanical cues, and many of these pathways are dysregulated in pathological conditions affecting bone. lncRNA is a group of RNAs with broad biogenesis, which are longer than 200 nt and highly conserved in their secondary and tertiary structures. Studies show that many lncRNAs are involved in normal development or balance of the skeletal system, the regulation of osteoblast differentiation, and the pathogenesis of osteosarcoma. Dysregulation of lncRNA expression is closely related to many bone diseases and it is expected to be a biomarker for predicting bone diseases. In this review, the characteristics and mechanisms of lncRNA involved in bone remodeling and its possible role were summarized, and the likely utility of IncRNAs as biomarkers and therapeutic targets for diseases of the skeletal system was discussed, including osteoarthritis, osteoporosis, and cancers of the skeletal system, so as to provide references for the better understanding and study on lncRNA biological function in organisms.