Objective To reduce the thrombosis probability and hemolysis risk of the meglev left ventricular assist device (LVAD), so as to increase the efficiency of blood supply. Methods The influences of the pump outlet diameter, exit angle, fillet size between the outlet and the inner wall of the pump, as well as gap between the rotor and the shell on internal flow field of the pump were studied by using the computational fluid dynamics (CFD) method, so as to optimize the internal structure and improve the hydrodynamic performance of the pump. Results Compared with pump of the previous generation, the maximum wall shear stress (WSS) of the pump inner wall, the maximum WSS of the pump rotor, the area with WSS >200 Pa were reduced by 23.6%, 47.4%, 76.2%, respectively, while the outlet flow was increased by 14.4%. Conclusions For the meglev LVAD of the new generation, its internal blood flow tended to be smooth, and the hemodynamic performance of blood flow was improved comprehensively. The research findings provide references for optimization design of the meglev LVAD and related experimental researches in the future.