Objective To study bone remodeling behavior under different damage conditions. Methods A bone remodeling model under fatigue mechanism was proposed. By establishing a three-dimensional (3D) finite element model of the proximal femur and combining with the finite element method, the bone remodeling under three loading conditions was simulated, and the mechanical properties and density changes of the proximal femur were analyzed. Results The damage increased with the number of loading cycles increasing. Under different damage conditions, bone showed different remodeling behaviors. As a kind of repair mechanism, bone remodeling could make up for the loss of bone mass due to fatigue damage within a certain range. Conclusions The damage adaptive remodeling model proposed in this study can simulate the bone remodeling behavior under different damage conditions, and the overload absorption caused by excessive loading cycles. The study on the behavior of bone remodeling under fatigue damage can provide references for fracture prevention and postoperative rehabilitation treatment.