Objective To investigate dynamic response of the finite element model of Lenke3 type scoliosis. Methods The finite element model was established based on CT scanning images from a patient with Lenke3 type scoliosis, and validation of the model was also conducted. Modal analysis, harmonic response analysis and transient dynamic analysis were carried out on the model. Results The first order natural frequency of this model was only 1-2 Hz.The amplitude of the finite element model was the largest at the first natural frequency. At the same resonance frequency, the amplitude of the thoracic curved vertebra was larger than that of the lumbar curved vertebra.The amplitude from T6 vertebra to L2 vertebra decreased successively. Conclusions The degree of spinal deformity may affect the perception of spine vibration, and the higher the degree of spinal deformity, the higher the sensitivity to vibration. The first natural frequency is most harmful to Lenke3 type scoliosis patients. Under cyclic loading, the thoracic curved vertebra is more prone to deformation than the lumbar curved vertebra. The closer to T1 segment, the greater the amplitude of the vibration is.