ABASTRACT: Objective：Anchorage of valve stent (i.e. anti-migration mechanical behavior) after interventional cardiac valve stent replacement is the key factor that affects the success and long-term effect of the operation. Therefore, this paper studies the anti-migration mechanical behavior of balloon-expanded aortic valve stent after implantation. Methods： A mechanical model of anti-migration of balloon-expanded valve stent after interventional treatment of aortic valve was established. The effects of different valve ring ellipticity, friction coefficient, valve stent material and calcification of autogenous valve leaflet on anti-migration of valve stent were studied by numerical simulation. Results： When the ovality of aortic valve ring is 0.2, 0.3, 0.4 and 0.5, the corresponding maximum migration force was 12.37N, 10.94N, 8.5N and 4.75N respectively; When the friction coefficient is 0.1, 0.2 and 0.3, the migration force of valve stent is 13.1N, 11N and 8.98N respectively; The anchoring performance of valve stent made of L605 cobalt-chromium alloy is better than that made of 316L stainless steel, and its corresponding maximum anti-migration force is 13.1N and 9.82N respectively; When the autogenous valve is calcified, the maximum migration force is 13.1N, while when the autogenous valve is not calcified, the maximum migration force is only 5.51N, The latter is 57.9% lower than the former. Conclusion： With the increase of the ovality of the valve ring, the anchoring of the valve stent decreases gradually; As the friction coefficient between the valve stent and the tissue increases, the migration force also increases; The anchoring performance of valve stent made of L605 cobalt-chromium alloy is superior to that made of 316L stainless steel; The anchoring of valve stent under calcification is better than that without calcification；The conclusions of this study will provide important scientific basis for the structural design and clinical selection of anti-migration valve stent.