Objective To study the biomechanical differences between hollow compression screws and shape-memory alloy staples in triple arthrodesis internal fixation and to provide references for the clinical application of shape-memory alloy staples. Methods Two-dimensional (2D) computed tomography (CT) foot data from a patient with severe horseshoe foot stiffness were selected, and a triple arthrodesis model was established using Mimics and Geomagic software. A geometric triple arthrodesis internal fixation model was established using SolidWorks 2021 software. Four fixation schemes (A, B, C, and D) were established according to the type and combination of fixed screws (hollow compression screws and shape-memory alloy riding nails). The biomechanical characteristics of models with different internal fixation schemes under neutral physiological loading were simulated and analyzed using ABAQUS software. Results The maximum end-face displacements of the fused surfaces of the talocalcaneal talonavicular and calcaneocuboid joints in the internal fixation model of scheme D were greater than those in schemes A, B, and C. The differences between the medial and lateral displacements of the fused surfaces of the talonavicular and calcaneocuboid joints in the internal fixation model of scheme D were 13.10% and 13.60%, respectively. The fused surface displacements were closer to the parallel displacements than those in the other three fixation schemes. The von Mises stresses were greater than those of schemes A, B, and C. Conclusions The application of scheme D (internal fixation at fusion surfaces of the talonavicular and calcaneocuboid joints with staples and at fusion surfaces of the talocalcaneal joints with compression hollow screws) provides stability at fusion surfaces of the internal fixation after triple arthrodesis surgery with near-parallel micromovement, which produces appropriate fusion stresses to make contact at the fusion end closer, promote the growth of bone scabs, and achieve better fusion results.